Nuclear phosphoinositide kinases and inositol phospholipids
نویسندگان
چکیده
منابع مشابه
Inositol polyphosphate kinases: regulators of nuclear function.
Recent work has uncovered roles for inositide signalling pathways downstream of phospholipase C activation and inositol 1,4,5-trisphosphate in the regulation of nuclear processes including gene expression, mRNA export and DNA metabolism. The identification of several IPKs (inositol polyphosphate kinases) has renewed interest in the cellular roles of inositol tetra-, penta-, hexa- and pyro-phosp...
متن کاملInositol phospholipids and cell regulation.
The increased turnover of phosphatidylinositol (PtdIns) in response to activation of cell-surface receptors was discovered by Hokin & Hokin (1953). The structures of the so-called polyphosphoinositides, phosphatidylinositol 4-phosphate (Ptdlns4P) and phosphatidylinositol 4,5-bisphosphate [PtdIns(4,5)P2], were not elucidated until the next decade, but their metabolic importance was suggested by ...
متن کاملThe inositol phospholipids.
T h e dried crystals melted with decomposition a t about 215”. The substance is probably an organic acid but we have not yet had time to examine it thoroughly.” (1) In this modest way inositol seems to have made its first appearance as a lipid constituent. Later in 1930, Anderson and Roberts (2) established the identity of their crystals, obtained from a phospholipid present in avian t...
متن کاملInhibiting phosphoinositide 3-kinases.
ISSN: 1538-4047 (Print) 1555-8576 (Online) Journal homepage: http://www.tandfonline.com/loi/kcbt20 Inhibiting phosphoinositide 3-kinases Yardena Samuels, Jiuxiang Zhu & Christoph Lengauer To cite this article: Yardena Samuels, Jiuxiang Zhu & Christoph Lengauer (2005) Inhibiting phosphoinositide 3-kinases, Cancer Biology & Therapy, 4:5, 546-547, DOI: 10.4161/cbt.4.5.1669 To link to this article:...
متن کاملInositol phospholipids: Translocation, translocation, translocation …
The pleckstrin homology (PH) domains of a number of proteins have been found to interact in vitro with inositol phospholipids; recent experiments show that these interactions may be important in directing protein translocation to specific parts of the cell following stimulus-induced lipid breakdown or synthesis.
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ژورنال
عنوان ژورنال: Journal of Cellular Biochemistry
سال: 2006
ISSN: 0730-2312,1097-4644
DOI: 10.1002/jcb.20655